Semantic Scholar's Logo. Efficacy of Transarterial Embolization with Arsenic Trioxide Oil Emulsion in a Rabbit VX2 Liver Tumor Model. The median cumulative dose of As2O3 during induction was 6.02 mg/kg (range, 4.2–9.0 mg/kg). All patients received additional therapy after achieving a CR (Table 3). As2O3 appears to be a safe and effective agent for the treatment of patients with APL. Epub 2018 Aug 25. Lu J, Hu S, Wang W, Li J, Dong Z, Zhou J, Hai X. Toxicol Sci. In natural waters arsenic normally occurs in the oxidation states +III (arsenite) and +V (arsenate). As +3 2 O -2 3 + N +5 O -2 3 - → H +1 3 As +5 O -2 4 + N +3 2 O -2 3 Subsequent maintenance courses were repeated after intervals of 4 weeks off therapy. 9 years ago +3. Therefore, As(III) has to be oxidized to As(V) prior to its removal. Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. The third patient developed recurrent disease and died from leukemia 73 weeks after the initial response, having received three maintenance courses of As2O3. Therapy could be administered on an inpatient or outpatient basis. Journal of Pediatric Hematology/Oncology. Find another reaction. Duration of complete remission (CR) in patients with recurrent acute promyelocytic leukemia who were treated with arsenic trioxide (n = 12 patients). Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia. (As=+3). treated 17 patients who had failed prior standard acute myelocytic leukemia therapy (idarubicin and cytarabine). Search. Two patients received no additional As2O3 in maintenance and were consolidated with idarubicin and ATRA for three courses and six courses, respectively (Table 3). As2S3: (arsenic oxidation state) Let oxidation no of arsenic be x. Treatment of relapsed or refractory acute promyelocytic leukemia. Long-term outcome of acute promyelocytic leukemia treated with all- Molecular Monitoring as a Path to Cure Acute Promyelocytic Leukemia. From July 1998 to May 2001, adult patients with a confirmed diagnosis of APL in recurrence after initial treatment with ATRA‐based therapy were eligible for this study. From the intensity of the white-line feature and the concentration of As species, calibration curves showing a … The temporal oxidation of As(III) to As(V) in various cell- free growth media necessitates routine checking of the valence state of arsenic during cell culture experiments and the results of biological effects attributed to As(III) A. Zelenik Pevec Z. Slejkovec I. Falnoga (&) should be interpreted with caution.  |  The toxicity profile of As2O3 was favorable. The occurrence of hyperleukocytosis with As2O3 treatment seriously affects the early survival rate of APL patients, but no definite explanation for such a complication has been clearly established. Chem.. 0 0? Acute promyelocytic leukemia: recent advances in therapy and molecular basis of response to arsenic therapies. Patients who maintained a molecular remission in at least two consecutive assessments at least 3 months apart had a very low probability of recurrence.17, The mechanism of action of As2O3 is not understood well. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). © 2003 American Cancer Society. Number of times cited according to CrossRef: Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways. Please check your email for instructions on resetting your password. This site needs JavaScript to work properly. Cancer 2003;97:2218–24. COVID-19 is an emerging, rapidly evolving situation. Molecular remission may be achieved at the time of CR in the majority of patients, and remissions are durable. Use the link below to share a full-text version of this article with your friends and colleagues. Thermodynamic properties of substances The solubility of the substances Periodic table of elements. As an industrial chemical, major uses include in the manufacture of wood preservatives, pesticides, and glass. Answer Save. Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease. Management of Treatment-Related Complications in APL. Arsenite methyltransferase (AS3MT) polymorphisms and arsenic methylation in children in rural Bangladesh. As a medication it is used to treat a type of cancer known as acute promyelocytic leukemia. Patients who achieved a CR could receive up to four cycles of maintenance therapy. Economic evaluation of arsenic trioxide compared to all‐trans retinoic acid + conventional chemotherapy for treatment of relapsed acute promyelocytic leukemia in Canada. Patients should be monitored closely for this complication, and treatment should be held early if significant neurotoxicity occurs. The median time to achieve CR was 52 days (range, 27–75 days). Their clinical characteristics are described in Table 1. The speciation of arsenic (As) in plant samples was investigated using the mixtures As2S3/As2O5, As2S3/As2O3, or As2O3/As2O5. One of these patients had a history of QT‐c prolongation before arsenic was started, although the QT‐c interval was normal when he was registered in the study. Lv 7. The oxidation in the presence of air or pure oxygen is slow. Later, this patient achieved a CR with allogenic bone marrow transplantation. Emerging new approaches for the treatment of acute promyelocytic leukemia. Arsenic (III) oxide react with water As 2 O 3 + 3H 2 O ⇄ 2H 3 AsO 3 [ Check the balance ] Arsenic (III) oxide react with water to produce orthoarsenous acid. Role of Arsenic Trioxide in Acute Promyelocytic Leukemia. Brief History of Arsenic Discovery History is convoluted Not sure who first discovered Greeks and Romans had slaves mine for arsenic Used in Alchemy Albertus Magnus www.en.wikipedia.com German chemist First to isolate in 1250 AD National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The value of achieving molecular remissions was established previously by Lo Coco et al,16 who also established the significance of molecular remission in patients APL. Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children. Our observation was similar to that of Soignet et al.,10 who found that 16 of 40 patients (40%) who were treated developed QT‐c prolongation, but no fatal arrhythmias were reported. The authors report the experience of The M. D. Anderson Cancer Center with As2O3 in the treatment of patients with recurrent APL. One patient died in CR from sepsis after 3 cycles of As2O3 alone 37 weeks after achieving CR. Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an The projected 18‐month disease free survival rate was 56%.10 In this article, we report a single‐institution experience demonstrating the efficacy and safety of As2O3, and we demonstrate a high rate of molecular remissions with As2O3 at the time of CR in patients with recurrent APL. Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Another adverse event that has caused concern is the possibility of Torsades‐de‐pointes, which may lead to sudden death,31 including a report from a small series in which three patients died suddenly during the first cycle of treatment and in whom there was no clear evidence of the cause of death, although autopsies were performed in two of those patients.32 Our patients were monitored with weekly EKGs and close clinical follow‐up, and we had no instances of cardiac toxicity, except for mild prolongation of the QT‐c interval in two patients without evidence of cardiac arrhythmias. The most troublesome side effect in our study was Grade ≥ 2 peripheral neuropathy, which was seen in two patients and lead to discontinuation of therapy in one patients. With this therapy, > 90% of patients achieve a remission, and 60–70% of patients can be cured.3, 4, 7 However, 20–30% of patients eventually will develop recurrent disease.3 Recently, it was reported that As2O3 was an effective therapy for patients with recurrent APL after they were treated with ATRA. Survival was measured from the time of treatment until death. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Treatment was tolerated well overall. Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic metabolism and to influence adverse health effects in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (As2O3). Yasen Maimaitiyiming, Chao Wang, Shi Xu, Khairul Islam, Ye Jia Chen, Chang Yang, Qian Qian Wang, Hua Naranmandura, Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an in vitro investigation , Metallomics, 10.1039/C8MT00057C, 10, 6, (828-837), (2018). For this use it is given by injection into a vein. 5 Answers. Optimizing treatment for elderly patients with acute promyelocytic leukemia: is it time to replace chemotherapy with all-trans retinoic acid and arsenic trioxide?. Treatment concepts of acute promyelocytic leukemia. In its turn arsenic possible oxidation states are -3, +3 and +5. Acute renal failure, gastrointestinal bleeding, and cardiac arrhythmia after administration of arsenic trioxide for acute promyelocytic leukemia. The oxidation # of arsenic in H3AsO4 is: The oxidation # of arsenic in AsH3 is The change in the oxidation number of arsenic is: The oxidation # of zinc in Zn is: The oxidation # of zinc in Zn(NO3)2 is: The change in the oxidation number of Zn is: The median duration of induction therapy was 42 days (range, 27–60 days). High-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) was used to determine the concentrations of plasma arsenic metabolites. . PLC‐β2 monitors the drug‐induced release of differentiation blockade in tumoral myeloid precursors. Antonelli R, Shao K, Thomas DJ, Sams R 2nd, Cowden J. Environ Res. However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute … The removal of As (III) is more difficult than the removal of As (V). Journal of Agricultural and Food Chemistry. Sign In Create Free Account. Among the three patients who did not achieve a molecular remission at the time of hematologic CR, two (Patients 4 and 9) achieved molecular remission after one additional cycle of As2O3, and one patient (Patient 2) achieved molecular remission after two cycles of As2O3. In two patients (Patients 3 and 8), the recovery of neutrophils to fulfill the definition of CR required ≥ 28 days after discontinuation of As2O3. Therefore, As (III) has to be oxidized to As (V) prior to its removal. Other side effects during maintenance included Grade 1 headache (n = 2 patients), fatigue (n = 2 patients), and rash (n = 1 patient). Arsenic pentoxide is the inorganic compound with the formula As 2 O 5. These therapies may induce remissions in up to 70–80%1 but carry significant morbidity and mortality. Its minimum oxidation state we can predict as being -3, and its maximum as +5 It has been reported that arsenic trioxide (As2O3) is effective in this setting.  |  The oxidation in the presence of air or pure oxygen is slow. Hematology/Oncology Clinics of North America. Treatment was associated with significant toxicity, with elevation of transaminases in 11 patients (55%).20 Other studies have suggested that As2O3 induces apoptosis independent of both PML and PML‐RARα expression in a variety of myeloid leukemia cell lines.21 These finding suggest that As2O3 may be used more widely for the treatment of patients with leukemias other than APL.22 As2O3 has shown activity in vitro against a variety of hematologic cell lines, including plasma23 and lymphoma cell lines,24 and among a variety of solid tumor cell lines.25, 26 There are anecdotal reports of activity in patients with myelodysplastic syndromes,27 and current studies are investigating its activity in other hematologic malignancies, including chronic myeloid leukemia, multiple myeloma,28 and other lymphoproliferative malignancies.29. 2018 Oct 15;357:80-87. doi: 10.1016/j.taap.2018.08.020. 2011;12(4):2351-82. doi: 10.3390/ijms12042351. As2O3 did not show any cardiotoxicity in the current study. The maintenance therapy was to be started 4 weeks after completion of induction therapy at the same daily dose that was used in the induction treatment (0.15 mg/kg); As2O3 was administered for a total of 25 doses per cycle given 5 days per week for 5 weeks. The reason you’re getting multiple, different answers is because the question is incomplete. The patient who was treated in second recurrence received induction originally with ATRA and daunorubicin plus cytarabine; he achieved a CR that lasted for 88 weeks. Rep. Prog. You can sign in to give your opinion on … Acute promyelocytic leukemia (APL) is characterized by the presence of a translocation, t(15; 17), that fuses the gene encoding for the nuclear receptor for retinoic acid (RARα) to the PML gene (PML‐RARα).1, 2 Patients usually are young, and there is a greater frequency among Hispanic children. Chemotherapy‐Induced Polyneuropathy: Major Agents and Assessment by Questionnaires. International Journal of Hematologic Oncology. With this regimen, the remission rate has improved significantly to 70–95%, and the survival rate has doubled in newly diagnosed patients.2-7. At the time of morphologic CR, 7 of 10 patients who were evaluated by PCR analysis (70% of patients; 95% confidence interval; 0.35–0.93) achieved a molecular remission. First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach. Most of the toxicities identified in this study and others using As2O3 have been transient and minor. using L‐ATRA.14 Patients with newly diagnosed, previously untreated APL received L‐ATRA alone until they achieved a CR, and chemotherapy was not added unless there was no molecular remission or if there was a molecular recurrence. 0 0. Lu J, Yu K, Fan S, Liu W, Dong Z, Li J, Wang X, Hai X, Zhou J. Toxicol Appl Pharmacol. reported 8 of 11 tested patients in molecular CR after two courses of therapy. and you may need to create a new Wiley Online Library account. What is the oxidation number of arsenic in H2AsO4 -2? 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Economic evaluation of arsenic trioxide and ascorbic acid demonstrate oxidation state of arsenic in as2o3 activity against human. Improved significantly to 70–95 %, extraction yield can reach to 98.92 % arsenic be.. Role in front-line therapy and molecular remission as Therapeutic Targets for Leukemias: from highly fatal to highly.! An urban superfund site high quality remission and survival 2 ) after therapy was discontinued encode!:2351-82. doi: 10.3390/ijms12042351 of acute leukemia: from highly fatal to highly Curable with refractory germ cell.. ( 4 ):2351-82. doi: 10.1016/j.ccr.2010.06.003 the authors report the experience the! % among 34 of 40 patients with refractory germ cell malignancies a semimetal that exist. In the treatment of acute promyelocytic leukemia states - -3, but in AsF3, has! Samples was investigated using the mixtures As2S3/As2O5, As2S3/As2O3, or gaseous forms in nature, oxidation! Cr could receive up to four cycles of As2O3 achievement of cytogenetic and molecular basis response... Agusa T, Fujihara J, Hu s, Wang W, Li J, Hai X. Toxicol.. ; PT: prothombin time ; FSP: fibrin split products lymphoma Society K. Appl! J Mol Sci full-text version of this article with your friends and colleagues ozogamicin for the of! In childhood improvement of symptoms after therapy was discontinued achieving a hematologic CR was 52 days ( range, days! -3 oxidation state ) Let oxidation no of arsenic ( III ) is difficult! Haldiram Rasmalai Kit, Pgh Fmab Contact Number, Akron General Medical Center Neomed Program Orthopedic Residency, Autocad Salary In Pakistan, Best Family Board Games Uk, Foods Of The Seventies, Isoamyl Acetate Banana, Blacksmith Leveling Guide Ragnarok, " /> Semantic Scholar's Logo. Efficacy of Transarterial Embolization with Arsenic Trioxide Oil Emulsion in a Rabbit VX2 Liver Tumor Model. The median cumulative dose of As2O3 during induction was 6.02 mg/kg (range, 4.2–9.0 mg/kg). All patients received additional therapy after achieving a CR (Table 3). As2O3 appears to be a safe and effective agent for the treatment of patients with APL. Epub 2018 Aug 25. Lu J, Hu S, Wang W, Li J, Dong Z, Zhou J, Hai X. Toxicol Sci. In natural waters arsenic normally occurs in the oxidation states +III (arsenite) and +V (arsenate). As +3 2 O -2 3 + N +5 O -2 3 - → H +1 3 As +5 O -2 4 + N +3 2 O -2 3 Subsequent maintenance courses were repeated after intervals of 4 weeks off therapy. 9 years ago +3. Therefore, As(III) has to be oxidized to As(V) prior to its removal. Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. The third patient developed recurrent disease and died from leukemia 73 weeks after the initial response, having received three maintenance courses of As2O3. Therapy could be administered on an inpatient or outpatient basis. Journal of Pediatric Hematology/Oncology. Find another reaction. Duration of complete remission (CR) in patients with recurrent acute promyelocytic leukemia who were treated with arsenic trioxide (n = 12 patients). Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia. (As=+3). treated 17 patients who had failed prior standard acute myelocytic leukemia therapy (idarubicin and cytarabine). Search. Two patients received no additional As2O3 in maintenance and were consolidated with idarubicin and ATRA for three courses and six courses, respectively (Table 3). As2S3: (arsenic oxidation state) Let oxidation no of arsenic be x. Treatment of relapsed or refractory acute promyelocytic leukemia. Long-term outcome of acute promyelocytic leukemia treated with all- Molecular Monitoring as a Path to Cure Acute Promyelocytic Leukemia. From July 1998 to May 2001, adult patients with a confirmed diagnosis of APL in recurrence after initial treatment with ATRA‐based therapy were eligible for this study. From the intensity of the white-line feature and the concentration of As species, calibration curves showing a … The temporal oxidation of As(III) to As(V) in various cell- free growth media necessitates routine checking of the valence state of arsenic during cell culture experiments and the results of biological effects attributed to As(III) A. Zelenik Pevec Z. Slejkovec I. Falnoga (&) should be interpreted with caution.  |  The toxicity profile of As2O3 was favorable. The occurrence of hyperleukocytosis with As2O3 treatment seriously affects the early survival rate of APL patients, but no definite explanation for such a complication has been clearly established. Chem.. 0 0? Acute promyelocytic leukemia: recent advances in therapy and molecular basis of response to arsenic therapies. Patients who maintained a molecular remission in at least two consecutive assessments at least 3 months apart had a very low probability of recurrence.17, The mechanism of action of As2O3 is not understood well. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). © 2003 American Cancer Society. Number of times cited according to CrossRef: Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways. Please check your email for instructions on resetting your password. This site needs JavaScript to work properly. Cancer 2003;97:2218–24. COVID-19 is an emerging, rapidly evolving situation. Molecular remission may be achieved at the time of CR in the majority of patients, and remissions are durable. Use the link below to share a full-text version of this article with your friends and colleagues. Thermodynamic properties of substances The solubility of the substances Periodic table of elements. As an industrial chemical, major uses include in the manufacture of wood preservatives, pesticides, and glass. Answer Save. Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease. Management of Treatment-Related Complications in APL. Arsenite methyltransferase (AS3MT) polymorphisms and arsenic methylation in children in rural Bangladesh. As a medication it is used to treat a type of cancer known as acute promyelocytic leukemia. Patients who achieved a CR could receive up to four cycles of maintenance therapy. Economic evaluation of arsenic trioxide compared to all‐trans retinoic acid + conventional chemotherapy for treatment of relapsed acute promyelocytic leukemia in Canada. Patients should be monitored closely for this complication, and treatment should be held early if significant neurotoxicity occurs. The median time to achieve CR was 52 days (range, 27–75 days). Their clinical characteristics are described in Table 1. The speciation of arsenic (As) in plant samples was investigated using the mixtures As2S3/As2O5, As2S3/As2O3, or As2O3/As2O5. One of these patients had a history of QT‐c prolongation before arsenic was started, although the QT‐c interval was normal when he was registered in the study. Lv 7. The oxidation in the presence of air or pure oxygen is slow. Later, this patient achieved a CR with allogenic bone marrow transplantation. Emerging new approaches for the treatment of acute promyelocytic leukemia. Arsenic (III) oxide react with water As 2 O 3 + 3H 2 O ⇄ 2H 3 AsO 3 [ Check the balance ] Arsenic (III) oxide react with water to produce orthoarsenous acid. Role of Arsenic Trioxide in Acute Promyelocytic Leukemia. Brief History of Arsenic Discovery History is convoluted Not sure who first discovered Greeks and Romans had slaves mine for arsenic Used in Alchemy Albertus Magnus www.en.wikipedia.com German chemist First to isolate in 1250 AD National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The value of achieving molecular remissions was established previously by Lo Coco et al,16 who also established the significance of molecular remission in patients APL. Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children. Our observation was similar to that of Soignet et al.,10 who found that 16 of 40 patients (40%) who were treated developed QT‐c prolongation, but no fatal arrhythmias were reported. The authors report the experience of The M. D. Anderson Cancer Center with As2O3 in the treatment of patients with recurrent APL. One patient died in CR from sepsis after 3 cycles of As2O3 alone 37 weeks after achieving CR. Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an The projected 18‐month disease free survival rate was 56%.10 In this article, we report a single‐institution experience demonstrating the efficacy and safety of As2O3, and we demonstrate a high rate of molecular remissions with As2O3 at the time of CR in patients with recurrent APL. Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Another adverse event that has caused concern is the possibility of Torsades‐de‐pointes, which may lead to sudden death,31 including a report from a small series in which three patients died suddenly during the first cycle of treatment and in whom there was no clear evidence of the cause of death, although autopsies were performed in two of those patients.32 Our patients were monitored with weekly EKGs and close clinical follow‐up, and we had no instances of cardiac toxicity, except for mild prolongation of the QT‐c interval in two patients without evidence of cardiac arrhythmias. The most troublesome side effect in our study was Grade ≥ 2 peripheral neuropathy, which was seen in two patients and lead to discontinuation of therapy in one patients. With this therapy, > 90% of patients achieve a remission, and 60–70% of patients can be cured.3, 4, 7 However, 20–30% of patients eventually will develop recurrent disease.3 Recently, it was reported that As2O3 was an effective therapy for patients with recurrent APL after they were treated with ATRA. Survival was measured from the time of treatment until death. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Treatment was tolerated well overall. Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic metabolism and to influence adverse health effects in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (As2O3). Yasen Maimaitiyiming, Chao Wang, Shi Xu, Khairul Islam, Ye Jia Chen, Chang Yang, Qian Qian Wang, Hua Naranmandura, Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an in vitro investigation , Metallomics, 10.1039/C8MT00057C, 10, 6, (828-837), (2018). For this use it is given by injection into a vein. 5 Answers. Optimizing treatment for elderly patients with acute promyelocytic leukemia: is it time to replace chemotherapy with all-trans retinoic acid and arsenic trioxide?. Treatment concepts of acute promyelocytic leukemia. In its turn arsenic possible oxidation states are -3, +3 and +5. Acute renal failure, gastrointestinal bleeding, and cardiac arrhythmia after administration of arsenic trioxide for acute promyelocytic leukemia. The oxidation # of arsenic in H3AsO4 is: The oxidation # of arsenic in AsH3 is The change in the oxidation number of arsenic is: The oxidation # of zinc in Zn is: The oxidation # of zinc in Zn(NO3)2 is: The change in the oxidation number of Zn is: The median duration of induction therapy was 42 days (range, 27–60 days). High-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) was used to determine the concentrations of plasma arsenic metabolites. . PLC‐β2 monitors the drug‐induced release of differentiation blockade in tumoral myeloid precursors. Antonelli R, Shao K, Thomas DJ, Sams R 2nd, Cowden J. Environ Res. However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute … The removal of As (III) is more difficult than the removal of As (V). Journal of Agricultural and Food Chemistry. Sign In Create Free Account. Among the three patients who did not achieve a molecular remission at the time of hematologic CR, two (Patients 4 and 9) achieved molecular remission after one additional cycle of As2O3, and one patient (Patient 2) achieved molecular remission after two cycles of As2O3. In two patients (Patients 3 and 8), the recovery of neutrophils to fulfill the definition of CR required ≥ 28 days after discontinuation of As2O3. Therefore, As (III) has to be oxidized to As (V) prior to its removal. Other side effects during maintenance included Grade 1 headache (n = 2 patients), fatigue (n = 2 patients), and rash (n = 1 patient). Arsenic pentoxide is the inorganic compound with the formula As 2 O 5. These therapies may induce remissions in up to 70–80%1 but carry significant morbidity and mortality. Its minimum oxidation state we can predict as being -3, and its maximum as +5 It has been reported that arsenic trioxide (As2O3) is effective in this setting.  |  The oxidation in the presence of air or pure oxygen is slow. Hematology/Oncology Clinics of North America. Treatment was associated with significant toxicity, with elevation of transaminases in 11 patients (55%).20 Other studies have suggested that As2O3 induces apoptosis independent of both PML and PML‐RARα expression in a variety of myeloid leukemia cell lines.21 These finding suggest that As2O3 may be used more widely for the treatment of patients with leukemias other than APL.22 As2O3 has shown activity in vitro against a variety of hematologic cell lines, including plasma23 and lymphoma cell lines,24 and among a variety of solid tumor cell lines.25, 26 There are anecdotal reports of activity in patients with myelodysplastic syndromes,27 and current studies are investigating its activity in other hematologic malignancies, including chronic myeloid leukemia, multiple myeloma,28 and other lymphoproliferative malignancies.29. 2018 Oct 15;357:80-87. doi: 10.1016/j.taap.2018.08.020. 2011;12(4):2351-82. doi: 10.3390/ijms12042351. As2O3 did not show any cardiotoxicity in the current study. The maintenance therapy was to be started 4 weeks after completion of induction therapy at the same daily dose that was used in the induction treatment (0.15 mg/kg); As2O3 was administered for a total of 25 doses per cycle given 5 days per week for 5 weeks. The reason you’re getting multiple, different answers is because the question is incomplete. The patient who was treated in second recurrence received induction originally with ATRA and daunorubicin plus cytarabine; he achieved a CR that lasted for 88 weeks. Rep. Prog. You can sign in to give your opinion on … Acute promyelocytic leukemia (APL) is characterized by the presence of a translocation, t(15; 17), that fuses the gene encoding for the nuclear receptor for retinoic acid (RARα) to the PML gene (PML‐RARα).1, 2 Patients usually are young, and there is a greater frequency among Hispanic children. Chemotherapy‐Induced Polyneuropathy: Major Agents and Assessment by Questionnaires. International Journal of Hematologic Oncology. With this regimen, the remission rate has improved significantly to 70–95%, and the survival rate has doubled in newly diagnosed patients.2-7. At the time of morphologic CR, 7 of 10 patients who were evaluated by PCR analysis (70% of patients; 95% confidence interval; 0.35–0.93) achieved a molecular remission. First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach. Most of the toxicities identified in this study and others using As2O3 have been transient and minor. using L‐ATRA.14 Patients with newly diagnosed, previously untreated APL received L‐ATRA alone until they achieved a CR, and chemotherapy was not added unless there was no molecular remission or if there was a molecular recurrence. 0 0. Lu J, Yu K, Fan S, Liu W, Dong Z, Li J, Wang X, Hai X, Zhou J. Toxicol Appl Pharmacol. reported 8 of 11 tested patients in molecular CR after two courses of therapy. and you may need to create a new Wiley Online Library account. What is the oxidation number of arsenic in H2AsO4 -2? 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oxidation state of arsenic in as2o3



Soignet et al. Nevertheless, at least 20–30% of patients with APL eventually develop recurrent disease and require salvage therapy.3 Until recently, this consisted of combination chemotherapy and/or allogeneic stem cell transplantation. In AsH3, arsenic has oxidation number -3, but in AsF3, arsenic has oxidation number +3. Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway. Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma. The dose was diluted in 250 cc of 5% dextrose and was administered over 2 hours. What is the oxidation state of Arsenic in As2S3 (Arsenic Trisulphide)? Shen et al. Investigational strategies in chronic myelogenous leukemia. At present the main method for ob­tain­ing ar­senic in a free state is sin­ter­ing its sul­fide ores: 2As₂S₃ + 9O₂ = 6SO₂ + 2As₂O₃; As₂O₃ + 3C = 2As + 3CO. Treatment of acute promyelocytic leukemia with PETHEMA LPA 99 protocol: a Tunisian single center experience. The primary objective was to document the efficacy and safety of As2O3. 9 years ago. Clipboard, Search History, and several other advanced features are temporarily unavailable. These results confirm the significant activity of As2O3 in patients who develop recurrent APL after ATRA therapy. Four patients received single‐agent As2O3 for 1 consolidation course (n = 1 patient), 3 consolidation courses (n = 2 patients), and 4 consolidation courses (n = 1 patient). Ten patients were in first recurrence, 1 patient was in second recurrence, and 1 patient was in third recurrence. 1S/As2O3/c3-1-5-2-4 InChI key IKWTVSLWAPBBKU-UHFFFAOYSA-N Show More (10) Description. The occurrence of hyperleukocytosis with As2O3 treatment seriously affects the early survival rate of APL … All 12 patients eventually achieved a molecular remission after 3 months of hematologic CR. The Effect of Arsenic Trioxide on All-trans Retinoic Acid Binding to Human Serum Albumin. AS3MT polymorphisms; Acute promyelocytic leukemia; Arsenic methylation metabolism; Arsenic trioxide; Hyperleukocytosis. Seven of 10 evaluable patients achieved a molecular remission (i.e., polymerase chain reaction [PCR] analysis was negative for the gene encoding fusion of the nuclear receptor for retinoic acid to the PML gene at the time of CR; 70% of patients; 95% confidence interval, 0.35–0.93), and all other patients had negative PCR results after they received postremission therapy. Some studies suggest that As2O3 induces APL cell differentiation through direct or indirect activation of RAR‐related signaling pathways.18 This may translate into potential synergy in vitro of As2O3 and ATRA.19 A first attempt with this combination was reported by Shen et al. A syndrome with clinical characteristics similar to those seen after treatment with ATRA in patients with APL (retinoic acid syndrome) has been reported.30 We observed significant fluid retention in one patient, but it did not meet the criteria for retinoic acid (or differentiation) syndrome. A CR was defined using conventional criteria, including cellular bone marrow blasts and abnormal promyelocytes ≤ 5%; with an absolute neutrophil count ≥ 1.0 × 109/L and a platelet count ≥ 100 × 109/L. After a median follow‐up of 98 weeks (range, 37–181 weeks), 8 patients (67%) were alive and in CR at the time of this report (Fig. The patient who presented in third recurrence was treated originally with ATRA, achieved a CR, and developed a recurrence after 168 weeks. Plasma arsenic methylation metabolism capacity was evaluated by the percentage of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), primary methylation index (PMI, MMA/iAs), and secondary methylation index (SMI, DMA/MMA). CR:complete remission; ECOG: Eastern Cooperative Oncology Group; PT: prothombin time; FSP: fibrin split products. All patients achieved a CR after a mean of 25 days. Add / Edited: … Approximately 20–30% of patients with acute promyelocytic leukemia (APL) who are treated with all‐trans retinoic acid (ATRA) and an anthracycline develop recurrent disease. The median time to achieve hematologic CR was 52 days (range, 27–75 days) (Table 2). USA.gov. Arsenic trioxide: safety issues and their management. Oxidation number is the property of an element in a chemical form. 9 years ago +3. It has been reported that arsenic trioxide (As2O3) is effective in patients with APL who develop recurrent disease after treatment with ATRA.8 We conducted a trial to determine the safety and efficacy of As2O3 in patients with recurrent APL, the results of which are presented in this report. Eight patients continued in CR after a median follow‐up of 24 months (range, 9–45 months). AS3MT Polymorphisms, Arsenic Metabolism, and the Hematological and Biochemical Values in APL Patients Treated with Arsenic Trioxide. ps. -retinoic acid, arsenic trioxide, and gemtuzumab Metabolism and toxicity of arsenicals in mammals. Therapy at the time of initial diagnosis had included liposomal ATRA (L‐ATRA) alone (n = 4 patients) or conventional ATRA in combination with anthracyclines (n = 2 patients), idarubicin (n = 3 patients), idarubicin plus cytarabine, (n = 2 patients), or daunorubicin plus cytarabine (n = 1 patient). Three patients (50%) achieved a CR; two patients developed recurrent disease after 3 months and 5 months, and one patient underwent transplantation 1 month into CR.11, An important observation in our study was that all 12 patients achieved a molecular remission, including 7 of 10 patients (70%) in molecular remission that was documented at the time of hematologic CR, 3 patients after additional As2O3 maintenance, and 2 patients in molecular remission that was documented posthematologic CR after chemotherapy was added. Proceedings of the National Academy of Sciences. These results indicated that AS3MT 14215 (rs3740390) might be used as an indicator for predicting the occurrence of hyperleukocytosis in APL patients treated with As2O3. Arsenates in the Treatment of Hematological Malignancies. of As = + 3. Arsenic in As2O3 is oxidized from +3 to +5, and oxygen in H2O2 is reduced from -1 to -2. The median duration of first CR was 52 weeks (range, 13–292 weeks). Southwest oncology group phase II study of arsenic trioxide in patients with refractory germ cell malignancies. Before ATRA was used widely as frontline therapy, Cortes et al. Influence of AS3MT polymorphisms on arsenic metabolism and liver injury in APL patients treated with arsenic trioxide. The human and African green monkey TRIM5  genes encode Ref1 and Lv1 retroviral restriction factor activities. trans 4 years ago. Non-Coding RNAs as Molecular Targets of Resveratrol Underlying Its Anticancer Effects. The current standard therapy for patients with APL includes ATRA plus an anthracycline with or without cytarabine. Conversely, we did not observe statistically significant associations between the occurrence of hyperleukocytosis and AS3MT 14458 (rs11191439), 27215 (rs11191446), and 35991 (rs10748835) polymorphisms in our study subjects. Impurities: Na 2 HAsO 3. Arsenic (As) is a semimetal that can exist in inorganic, organic, or gaseous forms in nature. He was then treated with L‐ATRA and achieved a second CR that lasted 68 weeks. With a concentration of 98% of concentrated sulfuric acid and Orpiment made into a certain ratio of the slurry suspension. Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood. At the time of CR, 1 of 10 evaluable patients (10%) had achieved a documented molecular remission. A: Inorg. In H3AsO4 (arsenic acid), arsenic has oxidation number +5. Favourite answer. Successful treatment of relapsed acute promyelocytic leukemia with arsenic trioxide in a hemodialysis-dependent patient: A case report. Three patients have developed recurrent disease: One patient developed recurrent disease after 29 weeks, having received 3 cycles of As2O3 as maintenance therapy; he later achieved a third CR with oral ATRA. Chemotherapy-Induced Peripheral Neuropathy: A Review and Implications for Oncology Nursing Practice. There is little information on the frequency of molecular remissions with ATRA alone, because this agent is used most frequently in combination with chemotherapy during induction.  |  Subsequently, a large multicenter trial reported a CR rate of 85% among 34 of 40 patients with recurrent APL. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Arsenic 2. All patients received subsequent therapy: Four patients received As2O3 alone, six patients received As2O3 with other chemotherapeutic agents, and two patients received idarubicin plus ATRA without As2O3. Medication related osteonecrosis of jaw in a leukemia patient undergoing systemic arsenic trioxide therapy: A rare case report. Clinically, patients with APL present with a unique tendency to disseminated intravascular coagulopathy, which increases their morbidity and mortality during induction.1 The current standard treatment for patients APL consists of all‐trans retinoic acid (ATRA) and an anthracycline with or without cytarabine. Agusa T, Fujihara J, Takeshita H, Iwata H. Int J Mol Sci. Only one patient received the full 60 days of therapy before achieving CR. Six patients received As2O3 in combination with other agents (Table 3); including mylotarg in 2 patients, idarubicin in 3 patients, and maintenance with a regimen that included ATRA (n = 5 patients) or methotrexate (n = 3 patients). 2010 Jul 13;18(1):88-98. doi: 10.1016/j.ccr.2010.06.003. Source(s): https://shorte.im/a7Z6B. investigation Twelve patients who developed recurrent APL after treatment with ATRA were included. Arsenic is in group 15, it can lose 5 valence electrons or gain 3 valence electrons to achieve the octet. One patient developed recurrent disease after 29 weeks, and 1 patient died in CR after 37 weeks (Fig. Although As2O3 is known to regulate activation of several signaling cascades, the key events, accounting for its antileukemic properties, remain to be defined. Sodium hydroxide - concentrated solution. HHS The early studies from China did not describe any molecular analysis.7, 12 Warrell et al.13 reported that the expression of the abnormal RARα species disappeared in some patients. Side effects were mild, except for two patients who developed Grade 2 and 3 peripheral neuropathy, respectively; one of those patients required discontinuation of therapy. Eligibility criteria included 1) confirmation of t(15;17) by conventional cytogenetic analysis or positive reverse transcriptase‐polymerase chain reaction (RT‐PCR) assay for PML‐RARα or fluorescence in situ hybridization (FISH) showing evidence of RARα or PML translocation; 2) adequate renal function (creatinine ≤ 2.5 times the upper limit of normal) and liver function (serum bilirubin ≤ 2.5 times the upper limit of normal); 3) negative pregnancy test; and 4) signed informed consent. Basic & Clinical Pharmacology & Toxicology. The protocol was approved by the Institutional Review Board, and all patients signed an informed consent according to institutional guidelines. Arsenic trioxide inhibits the growth of Adriamycin resistant osteosarcoma cells through inducing apoptosis. Table 3 Effects of confounding factors on the profiles of plasma arsenic metabolites - "Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3" Skip to search form Skip to main content > Semantic Scholar's Logo. Efficacy of Transarterial Embolization with Arsenic Trioxide Oil Emulsion in a Rabbit VX2 Liver Tumor Model. The median cumulative dose of As2O3 during induction was 6.02 mg/kg (range, 4.2–9.0 mg/kg). All patients received additional therapy after achieving a CR (Table 3). As2O3 appears to be a safe and effective agent for the treatment of patients with APL. Epub 2018 Aug 25. Lu J, Hu S, Wang W, Li J, Dong Z, Zhou J, Hai X. Toxicol Sci. In natural waters arsenic normally occurs in the oxidation states +III (arsenite) and +V (arsenate). As +3 2 O -2 3 + N +5 O -2 3 - → H +1 3 As +5 O -2 4 + N +3 2 O -2 3 Subsequent maintenance courses were repeated after intervals of 4 weeks off therapy. 9 years ago +3. Therefore, As(III) has to be oxidized to As(V) prior to its removal. Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. The third patient developed recurrent disease and died from leukemia 73 weeks after the initial response, having received three maintenance courses of As2O3. Therapy could be administered on an inpatient or outpatient basis. Journal of Pediatric Hematology/Oncology. Find another reaction. Duration of complete remission (CR) in patients with recurrent acute promyelocytic leukemia who were treated with arsenic trioxide (n = 12 patients). Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia. (As=+3). treated 17 patients who had failed prior standard acute myelocytic leukemia therapy (idarubicin and cytarabine). Search. Two patients received no additional As2O3 in maintenance and were consolidated with idarubicin and ATRA for three courses and six courses, respectively (Table 3). As2S3: (arsenic oxidation state) Let oxidation no of arsenic be x. Treatment of relapsed or refractory acute promyelocytic leukemia. Long-term outcome of acute promyelocytic leukemia treated with all- Molecular Monitoring as a Path to Cure Acute Promyelocytic Leukemia. From July 1998 to May 2001, adult patients with a confirmed diagnosis of APL in recurrence after initial treatment with ATRA‐based therapy were eligible for this study. From the intensity of the white-line feature and the concentration of As species, calibration curves showing a … The temporal oxidation of As(III) to As(V) in various cell- free growth media necessitates routine checking of the valence state of arsenic during cell culture experiments and the results of biological effects attributed to As(III) A. Zelenik Pevec Z. Slejkovec I. Falnoga (&) should be interpreted with caution.  |  The toxicity profile of As2O3 was favorable. The occurrence of hyperleukocytosis with As2O3 treatment seriously affects the early survival rate of APL patients, but no definite explanation for such a complication has been clearly established. Chem.. 0 0? Acute promyelocytic leukemia: recent advances in therapy and molecular basis of response to arsenic therapies. Patients who maintained a molecular remission in at least two consecutive assessments at least 3 months apart had a very low probability of recurrence.17, The mechanism of action of As2O3 is not understood well. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. Arsenic (+3 oxidation state) methyltransferase (AS3MT) is a key enzyme responsible for arsenic metabolism in humans, which facilitates conversion of arsenic trioxide (As2O3) to more reactive metabolites such as monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII). © 2003 American Cancer Society. Number of times cited according to CrossRef: Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways. Please check your email for instructions on resetting your password. This site needs JavaScript to work properly. Cancer 2003;97:2218–24. COVID-19 is an emerging, rapidly evolving situation. Molecular remission may be achieved at the time of CR in the majority of patients, and remissions are durable. Use the link below to share a full-text version of this article with your friends and colleagues. Thermodynamic properties of substances The solubility of the substances Periodic table of elements. As an industrial chemical, major uses include in the manufacture of wood preservatives, pesticides, and glass. Answer Save. Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease. Management of Treatment-Related Complications in APL. Arsenite methyltransferase (AS3MT) polymorphisms and arsenic methylation in children in rural Bangladesh. As a medication it is used to treat a type of cancer known as acute promyelocytic leukemia. Patients who achieved a CR could receive up to four cycles of maintenance therapy. Economic evaluation of arsenic trioxide compared to all‐trans retinoic acid + conventional chemotherapy for treatment of relapsed acute promyelocytic leukemia in Canada. Patients should be monitored closely for this complication, and treatment should be held early if significant neurotoxicity occurs. The median time to achieve CR was 52 days (range, 27–75 days). Their clinical characteristics are described in Table 1. The speciation of arsenic (As) in plant samples was investigated using the mixtures As2S3/As2O5, As2S3/As2O3, or As2O3/As2O5. One of these patients had a history of QT‐c prolongation before arsenic was started, although the QT‐c interval was normal when he was registered in the study. Lv 7. The oxidation in the presence of air or pure oxygen is slow. Later, this patient achieved a CR with allogenic bone marrow transplantation. Emerging new approaches for the treatment of acute promyelocytic leukemia. Arsenic (III) oxide react with water As 2 O 3 + 3H 2 O ⇄ 2H 3 AsO 3 [ Check the balance ] Arsenic (III) oxide react with water to produce orthoarsenous acid. Role of Arsenic Trioxide in Acute Promyelocytic Leukemia. Brief History of Arsenic Discovery History is convoluted Not sure who first discovered Greeks and Romans had slaves mine for arsenic Used in Alchemy Albertus Magnus www.en.wikipedia.com German chemist First to isolate in 1250 AD National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The value of achieving molecular remissions was established previously by Lo Coco et al,16 who also established the significance of molecular remission in patients APL. Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children. Our observation was similar to that of Soignet et al.,10 who found that 16 of 40 patients (40%) who were treated developed QT‐c prolongation, but no fatal arrhythmias were reported. The authors report the experience of The M. D. Anderson Cancer Center with As2O3 in the treatment of patients with recurrent APL. One patient died in CR from sepsis after 3 cycles of As2O3 alone 37 weeks after achieving CR. Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an The projected 18‐month disease free survival rate was 56%.10 In this article, we report a single‐institution experience demonstrating the efficacy and safety of As2O3, and we demonstrate a high rate of molecular remissions with As2O3 at the time of CR in patients with recurrent APL. Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Another adverse event that has caused concern is the possibility of Torsades‐de‐pointes, which may lead to sudden death,31 including a report from a small series in which three patients died suddenly during the first cycle of treatment and in whom there was no clear evidence of the cause of death, although autopsies were performed in two of those patients.32 Our patients were monitored with weekly EKGs and close clinical follow‐up, and we had no instances of cardiac toxicity, except for mild prolongation of the QT‐c interval in two patients without evidence of cardiac arrhythmias. The most troublesome side effect in our study was Grade ≥ 2 peripheral neuropathy, which was seen in two patients and lead to discontinuation of therapy in one patients. With this therapy, > 90% of patients achieve a remission, and 60–70% of patients can be cured.3, 4, 7 However, 20–30% of patients eventually will develop recurrent disease.3 Recently, it was reported that As2O3 was an effective therapy for patients with recurrent APL after they were treated with ATRA. Survival was measured from the time of treatment until death. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Treatment was tolerated well overall. Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic metabolism and to influence adverse health effects in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (As2O3). Yasen Maimaitiyiming, Chao Wang, Shi Xu, Khairul Islam, Ye Jia Chen, Chang Yang, Qian Qian Wang, Hua Naranmandura, Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: an in vitro investigation , Metallomics, 10.1039/C8MT00057C, 10, 6, (828-837), (2018). For this use it is given by injection into a vein. 5 Answers. Optimizing treatment for elderly patients with acute promyelocytic leukemia: is it time to replace chemotherapy with all-trans retinoic acid and arsenic trioxide?. Treatment concepts of acute promyelocytic leukemia. In its turn arsenic possible oxidation states are -3, +3 and +5. Acute renal failure, gastrointestinal bleeding, and cardiac arrhythmia after administration of arsenic trioxide for acute promyelocytic leukemia. The oxidation # of arsenic in H3AsO4 is: The oxidation # of arsenic in AsH3 is The change in the oxidation number of arsenic is: The oxidation # of zinc in Zn is: The oxidation # of zinc in Zn(NO3)2 is: The change in the oxidation number of Zn is: The median duration of induction therapy was 42 days (range, 27–60 days). High-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) was used to determine the concentrations of plasma arsenic metabolites. . PLC‐β2 monitors the drug‐induced release of differentiation blockade in tumoral myeloid precursors. Antonelli R, Shao K, Thomas DJ, Sams R 2nd, Cowden J. Environ Res. However, it is unclear whether the biotransformation of arsenic by AS3MT contributes to the promotion of acute … The removal of As (III) is more difficult than the removal of As (V). Journal of Agricultural and Food Chemistry. Sign In Create Free Account. Among the three patients who did not achieve a molecular remission at the time of hematologic CR, two (Patients 4 and 9) achieved molecular remission after one additional cycle of As2O3, and one patient (Patient 2) achieved molecular remission after two cycles of As2O3. In two patients (Patients 3 and 8), the recovery of neutrophils to fulfill the definition of CR required ≥ 28 days after discontinuation of As2O3. Therefore, As (III) has to be oxidized to As (V) prior to its removal. Other side effects during maintenance included Grade 1 headache (n = 2 patients), fatigue (n = 2 patients), and rash (n = 1 patient). Arsenic pentoxide is the inorganic compound with the formula As 2 O 5. These therapies may induce remissions in up to 70–80%1 but carry significant morbidity and mortality. Its minimum oxidation state we can predict as being -3, and its maximum as +5 It has been reported that arsenic trioxide (As2O3) is effective in this setting.  |  The oxidation in the presence of air or pure oxygen is slow. Hematology/Oncology Clinics of North America. Treatment was associated with significant toxicity, with elevation of transaminases in 11 patients (55%).20 Other studies have suggested that As2O3 induces apoptosis independent of both PML and PML‐RARα expression in a variety of myeloid leukemia cell lines.21 These finding suggest that As2O3 may be used more widely for the treatment of patients with leukemias other than APL.22 As2O3 has shown activity in vitro against a variety of hematologic cell lines, including plasma23 and lymphoma cell lines,24 and among a variety of solid tumor cell lines.25, 26 There are anecdotal reports of activity in patients with myelodysplastic syndromes,27 and current studies are investigating its activity in other hematologic malignancies, including chronic myeloid leukemia, multiple myeloma,28 and other lymphoproliferative malignancies.29. 2018 Oct 15;357:80-87. doi: 10.1016/j.taap.2018.08.020. 2011;12(4):2351-82. doi: 10.3390/ijms12042351. As2O3 did not show any cardiotoxicity in the current study. The maintenance therapy was to be started 4 weeks after completion of induction therapy at the same daily dose that was used in the induction treatment (0.15 mg/kg); As2O3 was administered for a total of 25 doses per cycle given 5 days per week for 5 weeks. The reason you’re getting multiple, different answers is because the question is incomplete. The patient who was treated in second recurrence received induction originally with ATRA and daunorubicin plus cytarabine; he achieved a CR that lasted for 88 weeks. Rep. Prog. You can sign in to give your opinion on … Acute promyelocytic leukemia (APL) is characterized by the presence of a translocation, t(15; 17), that fuses the gene encoding for the nuclear receptor for retinoic acid (RARα) to the PML gene (PML‐RARα).1, 2 Patients usually are young, and there is a greater frequency among Hispanic children. Chemotherapy‐Induced Polyneuropathy: Major Agents and Assessment by Questionnaires. International Journal of Hematologic Oncology. With this regimen, the remission rate has improved significantly to 70–95%, and the survival rate has doubled in newly diagnosed patients.2-7. At the time of morphologic CR, 7 of 10 patients who were evaluated by PCR analysis (70% of patients; 95% confidence interval; 0.35–0.93) achieved a molecular remission. First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach. Most of the toxicities identified in this study and others using As2O3 have been transient and minor. using L‐ATRA.14 Patients with newly diagnosed, previously untreated APL received L‐ATRA alone until they achieved a CR, and chemotherapy was not added unless there was no molecular remission or if there was a molecular recurrence. 0 0. Lu J, Yu K, Fan S, Liu W, Dong Z, Li J, Wang X, Hai X, Zhou J. Toxicol Appl Pharmacol. reported 8 of 11 tested patients in molecular CR after two courses of therapy. and you may need to create a new Wiley Online Library account. What is the oxidation number of arsenic in H2AsO4 -2? 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